Sunday, May 17, 2020

The Commercialization Of Flumist ( Medimmune ) The First...

The FDA approved in 2003 the commercialization of FluMist ® (MedImmune) the first influenza vaccine with attenuated virus. This trivalent vaccine is administrated via intranasal spray because the virus replicates in cells lining the nasopharynx [21–23]. Use of live-attenuated vaccine has been limited to individuals two through forty-nine years of age based on a failed efficacy to prevent febrile illness in adults fifty through sixty five years of age [22]. As in the TIV the first step for the vaccine production is the generation of the viral seeds that presents the circulating HA and NA and six internal segments (PA, PB1, PB2, NS, NP, M) from the cold-adapted (ca) A/Ann Arbor/6/60 or ca B/Ann Arbor/1/66 (the master donor virus for LAIV (MDV)) [24, 25]. The manufacture of approved FluMist ® is also based on the injection in embryonated eggs of the reassortant virus and the recovery of the allantoic fluid with the screening of the reassortant that grows well at 25 ºC (cold -adapted) and present restricted growth (ta) at 37-39 ºC and is attenuated (att). The vaccine is tested in the ferret model [22]. Once the reassortant virus is selected, it is then injected in fertilized eggs pathogen free (SPF) that are incubated between 48-72h at 35-37 ºC. The allantoic fluid is recovered and clarified by filtration. The virus is concentrated by ultrafiltration and diluted using a stabilizing agent to obtain the final sucrose and potassium phosphate concentration. The virus harvest is thenShow MoreRelatedMedimmune Case Essay753 Words   |  4 PagesMedImmune Case Study Background MedImmune is dedicated to helping patients live better lives through advances in science and medicine. Hundreds of thousands of patients have benefited from their products, which are designed to treat or prevent infectious diseases, cancer and inflammatory diseases (Wikipedia, 2012). Their extensive research and development efforts are focused on these same areas. MedImmune acquired FluMist when it purchased Aviron in 2002. FluMist is Aviron’s lead product for

Wednesday, May 6, 2020

The Literature Emerging From The African, Latin American,...

ASSIGNEMENT Of SOCIAL DEVELPOMENT DEPARTMENT OF SOCIAL WORK, UNIVERSITY OF DELHI, DELHI MA (SW), Semester III ARTICLE NAME -Gender, Households and Poverty Tracking Mediations of Macro Adjustment Programmes Submitted to - Dr. Seema Sharma Mr.Pratap Chandra Behra Submitted by-Raman M.A (Final YEAR) DATE OF SUBMISSION-20 OCT 2014 Introduction about the article The literature emerging from the African, Latin American, Caribbean and Asian countries that have adopted structural adjustment programmes throws light on the multidimensional of effects at the households’ level. This article captures significant areas from the literature around. (a) Women’s work, poverty and structural†¦show more content†¦After a brief overview of positions vis-à  -vis structural adjustment the significant areas of concern that emerge the literature around women’s work, poverty and structural adjustment and gender specific impact. In particular, this paper attempts to capture significant areas of concern that emerge from the literature around: women’s work, poverty and structural adjustment; household survival strategies; and growing orthodoxy and the extant critique around gender, poverty, household headship and household survival strategies. The proponents, who see’ the robes .If not for Structural Adjustment Policies(SAP),the countries the time of taking international monetary fund and world bank loans would have face more distress. The microeconomic theories and policies examined with respect to their varying impacts on men and women. The structural adjustment policies introduced in various countries within a context of pre-existing social and gender inequalities, evidently impact women negatively more than men. Hadled et al (1955) have attempted to examine country level studies to understand the impact of stabilization policies on women welfare. The examination of the gender implications of structural adjustment process has to investigate

Pearl Jam free essay sample

Words cannot describe the leap my heart took when I heard Pearl Jam would be releasing a new album, their first in four years. I immediately pre-ordered it, and nearly fainted when I checked the mail one day and saw that Pearl Jam’s self-titled album was in my possession. The album starts off with the same hard rock roots for which Pearl Jam is notorious, but I couldn’t help but notice that Eddie Vedder’s voice has noticeably aged and that the vocal moments when he would have roughened up and gone into a garage/punk mode have decreased. Those that do exist are less rough than I expected. Songs like â€Å"Comatose,† â€Å"Marker in the Sand† and some parts of â€Å"Life Wasted† almost sounded watered down. Nonetheless, amidst the aggressive blues soloing of Mike McCready and the intricate rhythm guitar work of Stone Gossard, Vedder’s cleaner singing voice fits in perfectly. We will write a custom essay sample on Pearl Jam or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The second half of the album is a bit better than the first, comprised of more intense songs which show off Vedder’s vocal range and ability to put massive amounts of emotion into his singing without getting emo. Songs like â€Å"Army Reserve† (co-written by Damien Echols of the West Memphis Three), the soul-tinged â€Å"Come Back† and the haunting â€Å"Gone† are perfect examples of what made Pearl Jam my favorite band, and arguably the best rock group out there. Hands-down, the best track on the album is the anthemic closer â€Å"Inside Job.† Clocking in at over seven minutes, it is chilling and uses a combination of acoustic and electric guitars with a magnificent piano part a la Boom Gaspar. Overall, this, like all Pearl Jam albums, has its moments of unparalleled raw emotion and pure musical intensity. It lacks, however, the track consistency that made earlier albums rock classics. Regardless, Pearl Jam remains one of the sure signs that true rock ’n’ roll hasn’t been brutally murdered by pop acts like Linkin Park. Pearl Jam free essay sample Pearl JamThe waiting drove me mad Youre finally here and Im a mess, sang Pearl Jams lead singer, Eddie Vedder. As I stood in my seat at Madison Square Garden, I realized that those lyrics to Corduroy described my emotions perfectly. I had waited five long years to see my favorite band play live.Once Pearl Jams long battle with Ticketmaster began, I feared that I would never see them live, but Pearl Jam pulled through. In early 1998, the band announced they would be touring to support their latest album, Yield, and would give in and play some Ticketmaster venues (like Madison Square Garden) so they could reach more fans. Like me!The opening act, Ben Harper and the Innocent Criminals, was, at best, mediocre. Ben Harper didnt foreshadow the stupendous show that was to come. Pearl Jam came on and brought with them a tremendous amount of energy. We will write a custom essay sample on Pearl Jam or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Guitarists Mike McCready and Stone Gossard bounced around the stage with the happiness of people who truly love their jobs. Along with bassist Jeff Ament and the regular crew, former Soundgarden drummer Matt Cameron joined the tour.It was apparent that Pearl Jam had put all their Ticketmaster troubles behind them. Even with their plummeting record sales, Pearl Jam has proved that they are true masters of their game. They may not have won their battle with Ticketmaster, but they showed that they are pragmatists who know when the fight is over. To me, they didnt lose. They came out of this ordeal showing that music was the reason they stayed together.The self-proclaimed moody Eddie Vedder was in rare form that night. He joked with the audience as if we were his old friends. Before the encores, several uniformed men came out carrying file boxes and told us this was the Ken Starr report! Pearl Jam played a good mix of new and old. Grunge rock anthems like Alive, Evenflow and Jeremy brou ght down the house. Vedder even stopped at certain points to let the crowd shout the lyrics we all knew so well. New songs (Do The Evolution and Wishlist) were just as moving. I was pleasantly surprised that they played some lesser known tunes, including my personal favorite, Elderly Woman.Pearl Jam showed that they had evolved from angst-ridden grunge rockers to veteran musicians who know their music would carry into the next millenniumVedder said, You aint nothing til you play Madison Square Garden, and I knew I had never heard a concert as good as this one until they did..